Specific breast milk nutrients may work together to influence cognitive abilities of 6-month-old infants

5 min read /
General Nutrition Neuroscience
Specific breast milk nutrients may work together to influence cognitive abilities of 6-month-old infants

Specific breast milk nutrients may work together to influence cognitive abilities of 6-month-old infants


  1. Martinez. Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr.1992;120 (4Pt 2):S129-38.
  2. Food and Agriculture Organization of the United Nations. Fats and fatty acids in human nutrition: report of an expert consultation. Food and Nutrition Paper 91, 2010. Accessed September 11, 2015 at http://www.fao.org/3/a-i1953e.pdf.
  3. Birch, et al. The DIAMOND Study: a double-masked, randomized controlled clinical trial of the maturation of infant visual acuity as a function of the dietary level of DHA. AJCN. 2010;91(4):848-859.
  4. Drover, et al. Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of DHA. Early Hum Dev. 2011;87(3):223-230.
  5. Anderson, et al. Proceedings: Polyunsaturated fatty acids of photo receptor membranes. Exp Eye Res. 1974;18(3):205-213.
  6. Zeisel. Nutritional importance of choline for brain development. AJCN. 2004;23(6):S621-S626.
  7. Alves-Rodrigues, et al. The science behind lutein. HYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed/15068825” Toxicol Lett. 2004;150(1): 57-83.
  8. Vishwanathan et al. Lutein and preterm infants with decreased concentration of brain carotenoids. JPGN. 2014;59:659-665.  
  9. DeLong, et al. Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. J Biol Chem. 1999;274:29683–29688.
  10. Watkins, et al. Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice. J Nutr. 2003;133:3386–3391.
  11. Li, et al. Choline redistribution during adaptation to choline deprivation. J Biol Chem. 2007;282:10283–10289.
  12. West, et al. Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester. AJCN. 2013;97(4):7 1 8 -727.
  13. Yan, et al. Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice. The FASEB J. 2014;28(10):4312-4323.
  14. Wurtman. Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents. Metabolism. 2008;57:S6–S10.
  15. Craciunescu, et al. Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus. J Nutr. 2003;133(11):3614-3618.
  16. Bazan, et al. Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, alzheimer’s, and other neurodegenerative diseases. Annu Rev Nutr. 2011;31:321–51.
  17. Götz, et al. Oxidative stress: free radical production in neural degeneration. HYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed/7972344” Pharmacol Ther. 1994;63(1):37-122.
  18. Arnal, et al. Lutein and docosahexaenoic acid prevent cortex lipid peroxidation in streptozotocin-induced diabetic rat cerebral cortex.” Neuroscience. 2010;166(1):271-278.
  19. Sachan, et al. Decreasing oxidative stress with choline and carnitine in women. AJCN. 2005;24(3):172-176.
  20. Jiang, et al. Choline inadequacy impairs trophoblast function and vascularization in cultured human placental trophoblasts. HYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed/?term=Choline+inadequacy+impairs+trophoblast+function+and+vascularization+in+cultured+human+placental+trophoblasts” J Cell Physiol. 2014; 229(8):1016-1027.


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